Covaxin booster neutralizes both omicron and delta forms: Bharat Biotech
– World Affairs SRS
The company said the Covaxin (BBV152) booster dose generated ‘strong neutralizing antibody responses’ against both Omicro (B.1.529) and Delta (B.1.617.2) using a live virus neutralization assay (test). It said that 100 percent of the test serum samples showed neutralization of the Delta variant, and more than 90 percent of the samples showed neutralization of the Omron variant.
The company today announced the results of a study conducted at Emory University that showed subjects receiving a booster dose of Covaxin (BBV 152) six months after receiving a primary two-dose series of Covaxin (BBV 152) Se sera neutralized SARS-CoV-2. Omicron and Delta variants.
Bharat Biotech said, “Earlier studies had demonstrated the neutralizing ability of Covaxin (BBV152) against SARS-CoV-2 variants of concern alpha, beta, delta, zeta and kappa.”
The study will be published shortly on the preprint server, medRXiv.
“Comparison of the neutralization activity of Covaxin-boosted sera with the Omicron variant observed in mRNA vaccine-boosted sera. More than 90% of all individuals incubated with Covaxin (BBV152) had neutralizing antibodies. All participants received an initial two-dose schedule of COVAXIN® (BBV152) on Day 0 and Day 28,” Bharat Biotech said.
The company said on Saturday that the booster dose study has yielded “promising” results. The phase 2, double blind, randomized controlled Covaxin trial demonstrated long-term safety without any serious adverse events, it said. A booster shot was given six months after the second dose of Covaxin.
“As the dominant COVID-19 variant worldwide, Omicron is a serious public health concern,” said Mehul Suthar, assistant professor at the Emory Vaccine Center and who led the laboratory analysis.
“The data from this preliminary analysis suggest that individuals receiving a booster dose of Covaxin have a significant immune response to both the omicron and delta forms. These findings suggest that the booster dose may increase disease severity and hospitalization.” There is the potential to undermine the ability to be recruited.”
Krishna Ella, chairman and managing director of Bharat Biotech, said they are in a ‘continuous’ state of innovation and product development for Covaxin.
“Positive neutralization responses against Omicron and delta variants validate our hypothesis of a multiple-epitope vaccine that induces both humoral and cell mediated immune responses. Our goals of developing a global vaccine against COVID-19 are supported by adults.” and has been achieved with the use of Covaxin as a universal vaccine for children,” he claimed.
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